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Which of the following infections can cause secondary Cold Antibody AIHA?

Rhinovirus

Syphilis

Cytomegalovirus

All of the above

The selection of "All of the above" is correct because various infections are associated with the development of secondary Cold Antibody Autoimmune Hemolytic Anemia (AIHA). In this condition, the immune system mistakenly produces antibodies that target the body's own red blood cells, leading to their destruction.

Rhinovirus, a common cause of the cold, can trigger the formation of cold agglutinins, which are antibodies that react at lower temperatures. Similarly, syphilis has also been linked to secondary AIHA through mechanisms that involve the immune response to infections. Cytomegalovirus (CMV) is known for its ability to induce various hematological abnormalities and can likewise stimulate the production of cold-reacting antibodies.

Each of these infectious agents demonstrates the ability to elicit an autoimmune response that can result in cold antibody AIHA, thereby supporting the inclusion of all three in the answer choice. Understanding how these infections contribute to secondary AIHA helps in managing and diagnosing this condition effectively.

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